| 2021 Iowa Football Schedule | | | | |
| 4-Sep | | Indiana | W | 34 | 6 | |
| 11-Sep | at | Iowa State | W | 27 | 17 | |
| 18-Sep | | Kent State | W | 30 | 7 | |
| 25-Sep | | Colorado State | W | 24 | 14 | |
| 1-Oct | at | Maryland | W | 51 | 14 | |
| 9-Oct | | Penn State | W | 23 | 20 | |
| 16-Oct | | Purdue | L | 7 | 24 | |
| 30-Oct | at | Wisconsin | L | 7 | 27 | |
| 6-Nov | at | Northwestern | W | 17 | 12 | |
| 13-Nov | | Minnesota | W | 27 | 22 | |
| 20-Nov | | Illinois | W | 33 | 23 | |
| 26-Nov | at | Nebraska | W | 28 | 21 | |
| 4-Dec | N | Michigan | L | 3 | 42 | Big Ten Championship- Indianapolis, IN |
| 1-Jan | N | Kentucky | L | 17 | 20 | Citrus- Orlando, FL |
| | 10-4-0 | | 328 | 269 | |
| | | | | | | |
| 2020 Iowa Football Schedule | | | | |
| 24-Oct | at | Purdue | L | 20 | 24 | |
| 31-Oct | | Northwestern | L | 20 | 21 | |
| 7-Nov | | Michigan State | W | 49 | 7 | |
| 13-Nov | at | Minnesota | W | 35 | 7 | |
| 21-Nov | at | Penn State | W | 41 | 21 | |
| 27-Nov | | Nebraska | W | 26 | 20 | |
| 5-Dec | at | Illinois | W | 35 | 21 | |
| 12-Dec | | Wisconsin | W | 28 | 7 | |
| | 6-2-0 | | 254 | 128 | |
| | | | | | |
